In the following question, out of the four alternatives, select the alternative which is the best substitute of the words/sentence. Of a disease or poison extremely severe or harmful in its effects

In the following question, out of the four alternatives, select the alternative which is the best substitute of the words/sentence.
Of a disease or poison extremely severe or harmful in its effects
1). Innocuous
2). Virulent
3). Naive
4). Inoffensive

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