Pick out the most effective word from the given words to fill in the blanks to make the sentence meaningfully complete

Pick out the most effective word from the given words to fill in the blanks to make the sentence meaningfully complete

People who have been through difficult, painful and not very?????..change efforts
often end up????.both pessimistic and angry conclusions.
1). successful, drawing
2). meaningful, projecting
3). reliable, evolving
4). strong, following

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